Pharmaceutical Formulations

Pharmaceutical formulation, in pharmaceutics, is the process in which different chemical substances, including the active drug, are combined to produce a final medicinal product. 

 

Internal formulations

Tablet : A tablet is usually a compressed preparation that contains:

  • 5-10% of the drug (active substance);
  • 80% of fillers, disintegrants, lubricants, glidants, and binders; and
  • 10% of compounds which ensure easy disintegration, disaggregation, and dissolution of the tablet in the stomach or the intestine.

Capsule: A capsule is a gelatinous envelope enclosing the active substance. Capsules can be designed to remain intact for some hours after ingestion in order to delay absorption. They may also contain a mixture of slow and fast release particles to produce rapid and sustained absorption in the same dose.

Sustained release: There are a number of methods by which tablets and capsules can be modified in order to allow for sustained release of the active compound as it moves through the digestive tract. One of the most common methods is to embed the active ingredient in an insoluble porous matrix, such that the dissolving drug must make its way out of the matrix before it can be absorbed.

Parenteral formulations

These are also called injectable formulations and are used with intravenous, subcutaneous, intramuscular, and intra-articular administration.

Liquids: Liquid drugs are stored in vials, IV bags, ampoules, cartridges, and prefilled syringes.

As with solid formulations, liquid formulations combine the drug product with a variety of compounds to ensure a stable active medication following storage. These include solubilizers, stabilizers, buffers, tonicity modifiers, bulking agents, viscosity enhancers/reducers, surfactants, chelating agents, and adjuvants.

Lyophilized : Lyophilized drugs are stored in vials, cartridges, dual chamber syringes, and prefilled mixing systems.

Lyophilization, or freeze drying, is a process that removes water from a liquid drug creating a solid powder, or cake. The lyophilized product is stable for extended periods of time and could allow storage at higher temperatures. In protein formulations, stabilizers are added to replace the water and preserve the structure of the molecule.

Topical formulations

Cutaneous:  Topical formulation include

  • Cream - Emulsion of oil and water in approximately equal proportions. Penetrates stratum corneum outer layers of skin well.
  • Ointment - Combines oil (80%) and water (20%). Effective barrier against moisture loss.
  • Gel - Liquefies upon contact with the skin.
  • Paste - Combines three agents - oil, water, and powder; an ointment in which a powder is suspended.
  • Powder - A finely subdivided solid substance.

 

    Related Conference of Pharmaceutical Formulations

    March 25-26, 2019

    World Congress on Pharmaceutical Biotechnology & Bioengineering

    Orlando, Florida, USA
    March 27-28, 2019

    5th International Conference on Clinical Pharmacy and
    Health Care

    San Antonio, Texas, USA
    April 04-06, 2019

    4th Annual Congress on Nanomedicine and Drug Delivery

    Auckland, NewZealand
    April 15-16, 2019

    12th European Biosimilars Congress

    Berlin, Germany
    April 17-18, 2019

    11th World Congress on Pharmacology & Therapeutics

    Montreal, Canada
    April 17-18, 2019

    Annual Neurochemistry and Neuropharmacology Congress

    | Montreal, Canada
    April 17-18, 2019

    International Conference on Global Analytica

    Osaka, Japan

    April 22-23, 2019

    20th Asia-Pacific Pharma Congress

    Tokyo, Japan
    April 25-26, 2019

    14th Annual Meet on Euro Ethnopharmacology

    Holiday Inn Amsterdam – Arena Towers | Hoogoorddreef 66a, 1101 BE Amsterdam, Netherlands
    May 01-02, 2019

    11th Annual Meet on Molecular Pharmacology 2019

    Amsterdam, Netherlands
    May 06-07, 2019

    11th World Congress on Neuropharmacology

    Prague, Czech Republic
    May 20-22, 2019

    21st Annual European Pharma Congress

    Zurich, Switzerland
    March 22-23, 2019

    5th International Conference on Antibiotics

    Orlando, USA
    June 14-15, 2019 |

    13th World Drug Delivery Summit

    Montreal, Canada
    July 29-30, 2019

    7th European Biopharma Congress

    Stockholm, Sweden
    June 27-28, 2019

    4th Pharmaceutical Chemistry Conference

    Amsterdam, Netherlands
    June 27-28, 2019

    18th Annual Congress on Pharmaceutics & Drug Delivery Systems

    Amsterdam, Netherlands
    June 27-28, 2019

    12th World Congress on Future Pharma

    Amsterdam, Netherlands
    July 15-16, 2019

    6th World Congress on Drug Discovery & Toxicology

    Abu Dhabi, UAE
    July 19-20, 2019

    8th International Conference on Clinical Trials

    | Atlanta, USA
    July 19-20, 2019

    8th International Conference on Clinical Trials

    | Atlanta, USA

    August 02-03, 2019

    9th International Conference on Pharmaceutical GMP, GCP & Regulatory Affairs

    | Pharmaceutical Research, Education, Expo & Networking | Chicago, USA
    August 19-20, 2019

    24th World Congress on Pharmacology

    Vienna, Austria
    September 11-12, 2019

    14th World Congress on Pharmacology and Toxicology

    Singapore
    September 11-12, 2019

    World Congress on Drug Discovery and Drug Design

    Singapore
    September 18-19, 2019

    6th World Congress on Natural Products, Medicinal Plants and Traditional Medicines

    | Radisson Narita | Tokyo, Japan
    October 10-11, 2019

    15th World Congress on Medicinal Chemistry & CADD

    Dubrovnik | Croatia
    October 14-15, 2019

    19th World Congress on Advances in Pharmaceutical Sciences

    Courtyard Marriott Seoul Times Square | Seoul, South Korea
    October 16-17, 2019

    Asia Pacific Pharmaceutics Congress

    Singapore
    November 03-04, 2019

    Advanced Pharmaceutics and Clinical Research

    | Paris, France
    September 11-12, 2019

    2nd Annual Pharmaceutical Biotechnology Congress

    Singapore
    November 11-12, 2019

    20th Annual Pharma Middle East Congress

    Istanbul, Turkey
    November 14-15, 2019

    2nd World Congress on Bioorganic and Medicinal Chemistry

    Cape Town, South Africa
    November 18-19, 2019

    27th Global Experts Meeting on Neuropharmacology

    Rome, Italy
    December 02-03, 2019

    14th World Congress on Pharmacology and Drug Safety

    Nice, France
    December 09-10, 2019

    20th World Congress on Analytical and Bioanalytical Chemistry

    Kuala Lumpur, Malaysia

    Pharmaceutical Formulations Conference Speakers

    Recommended Sessions

    Related Journals

    Are you interested in